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楚慧郢 助理研究员

楚慧郢 博士后


楚慧郢   助理研究员

电话:0411-84379875

E-mail:chuhy2009@dicp.ac.cn


教育工作经历

  • 2000.9-2004.7: 黑龙江大学生命科学学院,生物技术专业, 理学学士学位

  • 2004.9-2009.6: 吉林大学理论化学研究所,物理化学专业,硕博连读

  • 2009.8-2011.4:中国科学院大连化学物理研究所,分子模拟与设计研究组,博后

  • 2011.5月至今 中国科学院大连化学物理研究所,分子模拟与设计研究组,助理研究员


发表论文

1. Hui-Ying Chu(楚慧郢), Wang JA, Shen HJ, Yang YL, Zhu WL, Li GH. Investigation of Family 18 Chitinases and Inhibitors by Computer-aided Approaches Current Drug Targets, (Accept).
2. Hui-Ying Chu(楚慧郢), Zheng QC, Li X, Zhao YS, Zhang HX. DFT Investigation on the Reaction Mechanism Catalyzed by α-Phosphomannomutase1 in Protonated / Deprotonated states. JOURNAL OF MOLECULAR MODELING, DOI: 10.1007/s00894-010-0743-3.

3.

Hui-Ying Chu(楚慧郢), Qing-Chuan Zheng, Yong-Shan Zhao, Hong-Xing Zhang, “Homology modeling and Molecular dynamics study on N-acetylneuraminate lyase” Journal of Molecular Modeling. (2009) 15:323–328.

4.

Hui-Ying Chu(楚慧郢), Qing-Chuan Zheng, Yong-Shan Zhao, Hong-Xing Zhang, “Theoretical Studies on Interaction Mode Between human 2-Amino 3-carboxymuconate 6-semialdehyde Decarboxylase and Substrate and Inhibitor” Chem. J. Chinese Universities. 29(12) 2398-2402。

5.

Jun-Jie Xu, Jian Song, Fei Yan, Hui-Ying Chu(楚慧郢), Ji-Xun Luo, Yong-Shan Zhao, Xu Cheng, Gui-Ming Luo, Qing-Chuan Zheng, Jing-Yan Wei. Improving GPX activity of selenium-containing human single-chain Fv antibody by site-directed mutation based on the structural analysis. Journal Molecular Recognition. 2009, 22(4): 293-300..

6.

Yong-Shan Zhao, Qing-Chuan Zheng, Hong-Xing Zhang, Hui-Ying Chu(楚慧郢), Chia-Chung Sun. Analysis of a Three-Dimensional Structure of human Acidic Mammalian Chitinase Obtained by Homology Modeling and Ligand Binding Studies. Journal of molecular model. (2009) 15:499-505.

7.

Yong-Shan Zhao, Qing-Chuan Zheng, Hong-Xing Zhang, Hui-Ying Chu(楚慧郢), Chia-Chung Sun. Homology Modeling of Human Serine Racemase and Its Molecular Docking with Peptide Inhibitors. Acta Phys. Chim. Sin., 2009, 25(3):417-422.

8.

Qing-Chuan Zheng,Hui-Ying Chu(楚慧郢), Chia-Chung Sun. Theoretical studies on interaction models of human acetylcholine esterase (AChE) and inhibitors. SCIENCE CHINA Chemistry (Science in China Series B), 2009, 52 (11): 1911-1916.


科研项目

  • 教育部高等学校博士点学科专项科研基金:蛋白质结构和功能及分子间相互作用的理论研究

  • 国家十一五科技支持计划重点项目:含有毒元素材料的替代技术

  • 国家自然科学基金面上项目:大气中瞬变物种的激发态位能面和光化学反应动力学的理论研究

  • 国家自然科学基金面上项目:GSTP1酶类的作用机理及其抑制剂设计的理论研究

  • P450酶系中两类重要蛋白的理论研究